Thursday, November 1, 2018


7:00am - 8:00am


Genomics of Pediatric AML and MDS

Jeffery Klco, MD, PhD, St Jude Children's Research Hospital, Memphis, TN, USA

1:00pm - 2:30pm


Molecular Tumor Board

Elizabeth Swisher, MD, University of Washington, Seattle, WA, USA

Stephen Lincoln, Invitae, San Francisco, CA, USA

Eric H. Bernicker, MD, Houston Methodist Hospital, Houston, TX, USA

Valentina Nardi, Massachusetts General Hospital, Boston, MA, USA

Jonathan A. Nowak, MD, PhD, Brigham and Women's Hospital, Boston, MA, USA

Angela Jacobson, MS, University of Washington, Seattle, WA, USA

4:15pm - 5:45pm


Somatic and Germline Mutations in Hematologic Malignancies

Spliceosome Gene Mutations in MDS
Matthew Walter, MD, Washington University, St. Louis, MO, USA

Inherited Hematopoietic Malignancies
Lucy A. Godley, MD, PhD, The University of Chicago, Chicago, IL, USA

7:30pm - 8:30pm

Special Event: Emerging Targets for  the Diagnosis of Cancer: NTRK Fusion in Solid Tumors
Developed through a strategic collaboration between AMP and Medscape Education Oncology


Friday, November 2, 2018


7:00am - 8:00am


Keys to Publishing in Scientific Journals

Barbara A. Zehnbauer, PhD, Emory University School of Medicine, Atlanta, GA, USA

Case Studies in Solid Tumor

Circulating Tumor DNA (ctDNA) Detection in CSF in a Patient with Metastatic Melanoma to the CNS
Andres Moon, MD, University of Washington, Seattle, WA, USA

An Unusual Driver Mutation in a Lung Adenocarcinoma
Erik Nohr, MD, Stanford Healthcare, Palo Alto, CA, USA

LMNA/NTRK1 Fusion in a Paravertebral Soft Tissue Mass
Yulei Shen, MD, PhD, Baylor College of Medicine, Houston, TX, USA

Recurrent Glioblastoma with Primary and Secondary Features in a Patient with a Deficiency of Mismatch Repair
Martin Powers, MD, University of California San Diego, San Diego, CA, USA

8:15am - 9:45am


Tumoral Genomic Diversity

Predictor of Response to PARP Inhibitors
Elizabeth M. Swisher, MD, University of Washington, Seattle, WA, USA

Leveraging Personalized Medicine for Diagnosis and Treatment of Pancreatic Cancer
Brian Wolpin, MD, MPH, Dana-Farber Cancer Institute, Boston, MA, USA

10:45am - 11:45am


Platform Presentations of Selected Abstracts

Abstracts are selected by the Program Committee

Platform Presentations of Selected Hematopathology Abstracts

H025 - Ultradeep Error Corrected Next-generation Sequencing (NGS) of ABL1 Kinase Domain Mutations in BCR-ABL1 Positive Malignancies
Nikhil Patkar, MD, Tata Memorial Center, Mumbai, Maharashtra, India

H041 -  Longitudinal Monitoring of AML Tumors with High-throughput Single-Cell DNA Sequencing Reveals Rare Clones Prognostic for Disease Progression and Therapy Response
Dennis J. Eastburn, PhD, Mission Bio, Inc., South San Francisco, CA, USA

H014 - Mate Pair Sequencing: Ushering Cytogenetics Into the Era of Personalized Medicine
Nicole Hoppman, PhD, Mayo Clinic, Rochester, MN, USA

H039 - Donor-derived Clonal Hematopoiesis of Indeterminant Potential Mutations are Detected in Transplant Recipients after Allogeneic Hematopoietic Stem Cell Transplant
Jennifer Dunlap, MD, Oregon Health & Science University, Portland, OR, USA

Platform Presentations of Selected Solid Tumors Abstracts

ST002 - Analysis of Urinary Cell-free DNA for Early Detection and Surveillance of Bladder Cancer
Jonathan Dudley, MD, Stanford University, Stanford, CA, USA

ST055 - DNA Sequencing of Human, Epstein-Barr Virus, and Helicobacter Pylori Genomes to Classify and Monitor Gastric Adenocarcinoma
Margaret L. Gulley, MD, University of North Carolina, Chapel Hill, NC, USA

ST107 - Clinical Validation of MSK-ACCESS: An Ultrasensitive Next-generation Sequencing Assay for Liquid Biopsies in the Clinic
A. Rose Brannon, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, USA

ST144 - Prognosis Determined by Tumor Mutational Burden (TMB) Using Whole Exome Sequencing (WES)
Evan Fernandez, MS, Weill Cornell Medicine, New York, NY, USA

3:30pm - 5:00pm


Utilization of CRISPR/Cas Technique as Anti-Viral Therapeutic Agent and as an Adaptive Immune Modulator in DNA Editing and RNA Targeting

CRISPR/Cas9 Targeting and Inactivation of Viral DNA Genomes
Bryan R. Cullen, PhD, Duke University Medical Center, Durham, NC, USA

Programmable RNA-targeting CRISPR-Cas Enzymes for RNA Detection and Therapeutics
Mitchell R. O'Connell, PhD, University of Rochester, Rochester, NY, USA


Saturday, November 3, 2018


7:00am - 8:00am


AMP Guidance for Non-standard or Emerging NGS Applications: Liquid Biopsy

Christina Lockwood, PhD, University of Washington, Seattle, WA, USA

Christopher D. Gocke, MD, Johns Hopkins University, Baltimore, MD, USA

10:45am - 12:15pm


Clinical Implementation of Liquid Biopsy for Cancer Patients

Clinical Applications of Digital PCR
Maria Arcila, MD, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Liquid Biopsy for Solid Tumors: Promises and Perils

Mark Routbort, MD, PhD, University of Texas MD Anderson Cancer Center, Houston, TX, USA

1:30pm - 3:00pm


Finding the Patient Perspective: Molecular Testing in Advanced NSCLC

(Developed through a partnership between Medscape and the Association for Molecular Pathology)

Eric H. Bernicker MD, Houston Methodist Hospital, Houston, TX, USA

Christina Lockwood, PhD, University of Washington, Seattle, WA, USA

Lynette M. Sholl, MD, Brigham & Women's Hospital, Boston, MA, USA USA

Don Stranathan, Lung Cancer Survivor/Advocate, Santa Rosa, CA, USA

Precision Medicine in Mature Lymphoid Malignancies

Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia
Jennifer A. Woyach, MD, The Ohio State University, Columbus, OH, USA

Towards a Genomic Classification of T Cell Malignancies: Opportunities for Precision Medicine
Megan S. Lim, MD, PhD, University of Pennsylvania, Philadelphia, PA, USA

3:15pm - 4:45pm


Hypermutation and Mutation Signature Detection in Cancer

Clinical Implications of Mutational Load and Signatures on Replication Repair Deficiency in Cancer
Uri Tabori, MD, PhD, Hospital for Sick Children, Toronto, Ontario, Canada

Hypermutation in Cancer: Burden and Signatures of Mutational Processes
Ahmet Zehir, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, USA